Towards an exact orbital-free single-particle kinetic energy density for the inhomogeneous electron liquid in the Be atom

Holas and March (Phys. Rev. A51, 2040 (1995)) wrote the gradient of the one-body potential V(r) in terms of low-order derivatives of the idempotent Dirac density matrix built from a single Slater determinant of Kohn-Sham orbitals. Here, this is first combined with the study of Dawson and March (J. Chem. Phys. 81, 5850 (1984)) to express the single-particle kinetic energy density of the Be atom ground-state in terms of both the electron density n(r) and potential V(r). While this is the more compact formulation, we then, by removing V(r), demonstrate that the ratio t(r)/n(r) depends, though non-locally, only on the single variable n'(r)/n(r), no high-order gradients entering for the spherical Be atom.Comment: Submitted to Journal of Mathematical Chemistr

Narrative Change in Professional Wrestling: Audience Address and Creative Authority in the Era of Smart Fans

This dissertation project provides a methodological contribution to the field of critical rhetoric by positioning narrative theory as a powerful yet underutilized tool for examining the power dynamic between producer and consumer in a participatory media context. Drawing on theories of author and audience from rhetorical narratology, this study shows how producers of media texts provide rhetorical cues to audiences that allow them to reassert their power in the form of creative authority vis-à-vis consumers. The genre of professional wrestling serves as an ideal text for examining such power dynamics, as WWE has adapted to changing fan participatory behaviors throughout its sixty-year history. Focusing on pivotal moments in which WWE altered its narrative address to its audience in order to reassert its control over the production process, this study demonstrates the utility of narrative theory for understanding how creative authority shows power at work in media texts. Further, this study situates rhetorical narratology in conversation with theories of rhetorical persona, scholarship on subcultures, and the discursive construction of the “people.” In so doing, I show how a nuanced understanding of author and audience augments critical rhetorical scholarship’s focus on power. Finally, by applying narrative theory as a method for both close textual analysis of single texts as well as a tool for piecing together a critical text from narrative fragments, I also address questions of the role of the text in rhetorical criticism and the role of authorship in an era when audiences exert influence on media texts as they are produced

The re-emergence of the B1 cell compartment : is this a pre-lymphoma stage?

Chronic Lymphocytic Leukemia (CLL) are in some cases stereotyped for immunoglobulin variants in different populations, suggesting emergence of B cell subsets following presentation of the same antigen. CLL cells may originate from CD5+ naïve cells and from CD5 memory cells. Gene expression studies characterized a common cell of origin of the two clinical categories of CLL; the unmutated aggressive type and the mutated indolent type. The aim of this study was to investigate the presence of CD5 positive B cells in the elderly and their potential stimulation with exosomes derived from tumor cells. The findings from this study is aimed to create a model to identify instigating carcinomatous factors that may stimulate B1 cells to transform into a CLL-like model. In this study we show that CD19\textsuperscript+ cells (B cells) in cord blood have a high expression of CD5. CD19/CD5 staining of blood samples from senior citizens showed the presence of B cells which also express the CD5 marker, though at a lower expression when compared to CLL cells (CD19+/CD5 dim B cells). Measurement of clonality using λ/Κ flow cytometry staining show a monoclonal origin of the human CD19+/CD5 dim B cells. Monoclonal B cell Lymphocytosis in the elderly is a potential cell compartment that represents the origin of B cell proliferative disorders. The origin of the B cell proliferative disease requires antigen stimulation. A preliminary experiment showed that sorted lymphocytes can be stimulated by exosomes isolated from 2 cancer cells lines, A549 (lung epithelial) and PC3 (prostate cell line). In comparison with phytohaemagglutinin (PHA) and phorbolmyristate acetate (PMA), known lymphocyte stimulators, the exosomes stimulated the proliferation of monocytic-like cells. Further characterization is required to know the origin of these cells. The result shows that one can speculate that exosomes present cancer-derived antigens and stimulate cell proliferation. Further studies are required to evaluate the potential transformation capacity of cancer-derived exosomes. In addition, various cytokines were measured in the sera of senior citizens to investigate a differential release of cytokines in the presence or absence of the CD19+/CD5 dim B cells. Cytokines examined were not significantly different between the 2 groups and further evaluation of cytokine levels is required.peer-reviewe

Design of the Bastei OS Architecture

In the software world, high complexity of a problem solution comes along with a high risk for bugs and vulnerabilities. This correlation is particular perturbing for todays commodity operating systems with their tremendous complexity. The numerous approaches to increase the user’s confidence in the correct functioning of software comprise exhaustive tests, code auditing, static code analysis, and formal verification. Such quality-assurance measures are either rather shallow or they scale badly with increasing complexity. The operating-system design presented in this paper focuses on the root of the problem by providing means to minimize the underlying system complexity for each security-sensitive application individually. On the other hand, we want to enable multiple applications to execute on the system at the same time whereas each application may have different functional requirements from the operating system. Todays operating systems provide a functional superset of the requirements of all applications and thus, violate the principle of minimalism for each single application. We resolve the conflict between the principle of minimalism and the versatility of the operating system by decomposing the operating system into small components and by providing a way to execute those components isolated and independent from each other. Components can be device drivers, protocol stacks such as file systems and network stacks, native applications, and containers for executing legacy software. Each application depends only on the functionality of a bounded set of components that we call application-specific trusted computing base (TCB). If the TCBs of two applications are executed completely isolated and independent from each other, we consider both TCBs as minimal. In practice however, we want to share physical resources between multiple applications without sacrificing their independence. Therefore, the operating-system design has to enable the assignment of physical resources to each application and its TCB to maintain independence from other applications. Furthermore, rather than living in complete isolation, components require to communicate with each other to cooperate. The operating-system design must enable components to create other components and get them to know each other while maintaining isolation from uninvolved parts of the system. First, we narrow our goals and pose our mayor challenges in Section 1. Section 2 introduces our fundamental concepts and protocols that apply to each component in the system. In Section 3, we present the one component that is mandatory part of each TCB, enables the bootstrapping of the system, and provides abstractions for the lowest-level resources. We exercise the composition of the presented mechanisms by the means of process creation in Section 4

Sluice gate discharge of stratified flow

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Sanitary Engineering, 1954.Includes bibliographical references (leaf 29).by Carroll C. Jacobson, Jr, Norman R. Rosen.M.S

Are Measured Differences Between the Formants of Men, Women and Children Due to F0 Differences?

Formant measurements show sex and age differences in the formant patterns of a single vowel category. Comparisons of the formant frequency values of men, women and children indicate low, middle and high values, respectively (Chiba & Kajiyama 1941, Potter & Steinberg 1950, Peterson & Barney 1952). The differences are found for all vowel categories, and they have generally been interpreted as a consequence of different vocal tract siz

Three-dimensional hindfoot alignment measurements based on biplanar radiographs: comparison with standard radiographic measurements

Objective: To establish a hindfoot alignment measurement technique based on low-dose biplanar radiographs and compare with hindfoot alignment measurements on long axial view radiographs, which is the current reference standard. Materials and methods: Long axial view radiographs and low-dose biplanar radiographs of a phantom consisting of a human foot skeleton embedded in acrylic glass (phantom A) and a plastic model of a human foot in three different hindfoot positions (phantoms B1-B3) were imaged in different foot positions (20° internal to 20° external rotation). Two independent readers measured hindfoot alignment on long axial view radiographs and performed 3D hindfoot alignment measurements based on biplanar radiographs on two different occasions. Time for three-dimensional (3D) measurements was determined. Intraclass correlation coefficients (ICC) were calculated. Results: Hindfoot alignment measurements on long axial view radiographs were characterized by a large positional variation, with a range of 14°/13° valgus to 22°/27° varus (reader 1/2 for phantom A), whereas the range of 3D hindfoot alignment measurements was 7.3°/6.0° to 9.0°/10.5° varus (reader 1/2 for phantom A), with a mean and standard deviation of 8.1° ± 0.6/8.7° ± 1.4 respectively. Interobserver agreement was high (ICC = 0.926 for phantom A, and ICC = 0.886 for phantoms B1-B3), and agreement between different readouts was high (ICC = 0.895-0.995 for reader 1, and ICC = 0.987-0.994 for reader 2) for 3D measurements. Mean duration of 3D measurements was 84 ± 15/113 ± 15s for reader 1/2. Conclusion: Three-dimensional hindfoot alignment measurements based on biplanar radiographs were independent of foot positioning during image acquisition and reader independent. In this phantom study, the 3D measurements were substantially more precise than the standard radiographic measurement

Utilization of the halophytic shrubs Atriplex nummularia Lindl and Rhagodia preissii Moq as crops in salt-affected semi-arid regions:How temperature, salinity, seed weight and size affect seed germination

The perennial halophytic shrubs Atriplex nummularia and Rhagodia preissii are native to Australia and can be planted on saline land to produce sheep and cattle feed during the autumn. However, an impediment to the adoption of the species on saline land has been the challenges in achieving successful establishment by direct seeding due to a lack of knowledge of the optimal conditions for germination. Therefore, the optimal germination requirements in relation to temperature, salinity level and seed size was assessed for each species to ascertain the optimal conditions for successful establishment by direct seeding on saline land. Seeds of both species showed optimal germination temperature at 10°C. Atriplex nummularia seeds were more tolerant to temperatures above or below 10°C than R. preissii. The germination percentage of A. nummularia was unchanged at 0–200 mM NaCl(2). The germination percentage of Rhagodia preissii declined when the NaCl(2) content exceeded 50 mM. There was no correlation between seed size, germination and emergence for any of the species. Based on the study, we suggest that sowing operations are performed during the cold winter months in subtropical areas or autumn and spring in temperate areas, to improve the successful establishment of these shrubs by direct seeding

The place of downstaging for hepatocellular carcinoma

In the treatment of hepatocellular carcinomas, therapies such as trans-arterial chemo-embolisation, trans-arterial radioembolisation, percutaneous ethanol injection and radio-frequency ablation can decrease the size (and overall viability) of the tumours, thus potentially increasing the proportion of patients qualifying for resection and transplantation.While the use of such downstaging therapies is straightforward when resection is the aim, in a similar way to other neo-adjuvant treatments in the surgery of tumours that are too large or awkwardly placed to be primarily resected the issues related to transplantation are more complex. In the context of transplantation the word “downstaging” designates not only a neo-adjuvant treatment, but also a selection strategy to allow patients who are initially outside accepted listing criteria to benefit from transplantation should the neo-adjuvant therapy be successful in reducing tumour burden. The effectiveness of downstaging as a selection strategy, at first questioned because of methodological bias in the studies that described it, has been recently demonstrated by more solid prospective investigations. Several issues however remain open, such as inclusion criteria before the strategy is implemented (size/number, surrogate markers of differentiation/vascular invasion such as alpha-fetoprotein), the choice of which downstaging therapy, the end-points of treatment, and the need and duration of a period of observation proving disease response or stabilisation before the patient can be listed.The present review discusses which treatments and strategies are available for downstaging HCC on the basis of the published literature